N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Base Information

Chemical Name:N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide
CAS No.:1264366-92-8
Molecular Formula:C₂₀H₂₀N₂O₅
Molecular Weight:368.389
Hs Code.:

Synonyms:N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

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Technology Process of N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

There total 8 articles about N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1264366-80-4
N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

: 1264366-92-8
N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 42h;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1264366-61-1
4-(benzyloxycarbonyl)phenylisocyanide

: 1264366-92-8
N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 42 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; isopropyl alcohol; toluene; 1: Ugi condensation / 2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1264366-66-6
C₂₇H₂₈N₂O₆

: 1264366-92-8
N-(4-carboxyphenyl)-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 42 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077