5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester
• CAS No.: 179898-59-0
• Molecular Formula: C₃₀H₃₀ClNO₃
• Molecular Weight: 488.026

Synonyms:5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

Chemical Property of 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

There total 3 articles about 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene (179894-98-5) → 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester (179898-59-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jm980723h

Reference yield:

4-chlorophenyl lithium (14774-78-8) → 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester (179898-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) TFA, Et₃SiH / 1.) THF, -30 deg, 2.) CH₂Cl₂, RT

2: 59 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

With triethylsilane; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; hexane;

DOI:10.1021/jm980723h

Reference yield:

2,2,4-trimethyl-1,2-dihydro-6-oxa-1-azachrysen-5-one (179894-93-0) → 5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester (179898-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) TFA, Et₃SiH / 1.) THF, -30 deg, 2.) CH₂Cl₂, RT

2: 59 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

With triethylsilane; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; hexane;

DOI:10.1021/jm980723h

upstream raw materials:

di-tert-butyl dicarbonate

5-(4-chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene

4-chlorophenyl lithium

2,2,4-trimethyl-1,2-dihydro-6-oxa-1-azachrysen-5-one

Downstream raw materials:

5-(4-chlorophenyl)-1,2,3,4-tetrahydro-4-hydroxy-2,2-dimethyl-5H-chromeno[3,4-f]quinoline

5-(4-chloro-phenyl)-2,2-dimethyl-2,3-dihydro-1H,5H-6-oxa-1-aza-chrysen-4-one

5-(4-chloro-phenyl)-2,2-dimethyl-4-oxo-2,3,4,5-tetrahydro-6-oxa-1-aza-chrysene-1-carboxylic acid tert-butyl ester

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