(1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

Base Information

• Chemical Name: (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate
• CAS No.: 1009036-48-9
• Molecular Formula: C₄₀H₇₄O₆Si₂
• Molecular Weight: 707.195
• Mol file: 1009036-48-9.mol

Synonyms:(1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

Chemical Property of (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

There total 1 articles about (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid (1009036-47-8) + <3R,4R>-4-methyl-5-hexen-3-ol (95273-29-3) → (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate (1009036-48-9)

Guidance literature:

(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

<3R,4R>-4-methyl-5-hexen-3-ol; With dmap; In benzene; for 13h; Further stages.;

DOI:10.1021/jo702384d

Reference yield: 76.0%

(1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate (1009036-48-9) → (1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilanyloxy)-9-hydroxy-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate (1009036-49-0)

Guidance literature:

With camphor-10-sulfonic acid; In methanol; at 0 ℃; for 1h;

DOI:10.1021/jo702384d

upstream raw materials:

(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

<3R,4R>-4-methyl-5-hexen-3-ol

Downstream raw materials:

(1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilanyloxy)-9-hydroxy-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate