(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

Base Information

Chemical Name:(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid
CAS No.:1009036-47-8
Molecular Formula:C₃₃H₆₂O₆Si₂
Molecular Weight:611.023
Hs Code.:

Synonyms:(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

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Chemical Property of (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

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Technology Process of (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

There total 1 articles about (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1009036-46-7
(R)-4-benzyl-3-[(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-nonanoyl]oxazolidin-2-one

: 1009036-47-8
(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1021/jo702384d

Reference yield: 95.0%

: 1009036-47-8
(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

: 95273-29-3
<3R,4R>-4-methyl-5-hexen-3-ol

: 1009036-48-9
(1R,2R)-1-ethyl-2-methylbut-3-enyl (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

Guidance literature:: (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

<3R,4R>-4-methyl-5-hexen-3-ol; With dmap; In benzene; for 13h; Further stages.;
DOI:10.1021/jo702384d

Reference yield: 82.0%

: 1009036-47-8
(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

: 1198600-34-8
(3S,4R)-3-methylhex-1-ene-3,4-diol

: 1353285-66-1
(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3,9-bis-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

Guidance literature:: (2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

(3S,4R)-3-methylhex-1-ene-3,4-diol; With dmap; In benzene; at 20 ℃; for 15h;
DOI:10.1021/jo201158q