N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Base Information

Chemical Name:N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide
CAS No.:1342890-83-8
Molecular Formula:C₂₃H₂₈N₂O₅S
Molecular Weight:444.552
Hs Code.:

Synonyms:N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

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Technology Process of N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

There total 7 articles about N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1342890-83-8
N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:

Reference yield:

: 1342891-48-8
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)cyclobutanamine

: 23095-31-0
3,4-dimethoxybenzene-1-sulfonyl chloride

: 1342890-83-8
N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm201018g

Reference yield:

: 1342891-40-0
2-bromo-5-((2-methylbut-3-yn-2-yl)oxy)pyridine

: 1342890-83-8
N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.5 h / 130 °C / Microwave irradiation

2.1: n-butyllithium / tetrahydrofuran / 0.58 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: zinc(II) chloride / methanol / 2 h / 20 °C

3.2: 20 °C

4.1: triethylamine / dichloromethane

With n-butyllithium; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; 1.1: Claisen rearrangement;
DOI:10.1021/jm201018g