CN-Phe-Leu-OMe

Base Information

• Chemical Name: CN-Phe-Leu-OMe
• CAS No.: 1112971-02-4
• Molecular Formula: C₁₇H₂₂N₂O₃
• Molecular Weight: 302.373
• Mol file: 1112971-02-4.mol

Synonyms:CN-Phe-Leu-OMe

Chemical Property of CN-Phe-Leu-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CN-Phe-Leu-OMe

There total 1 articles about CN-Phe-Leu-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-formyl-(S)-phenylalanyl-(S)-leucine methyl ester (97058-71-4) → CN-Phe-Leu-OMe (1112971-02-4)

Guidance literature:

With 2,6-dimethylpyridine; bis(trichloromethyl) carbonate; In dichloromethane; at -60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01761

Reference yield: 81.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + CN-Phe-Leu-OMe (1112971-02-4) + 2,4-Dimethoxybenzylamine (20781-20-8) + Cbz-Tyr(tBu)-Gly-Ile-OH → Cbz-Tyr(tBu)-Gly-Ile-N(DMB)Gly-Phe-Leu-OMe

Guidance literature:

formaldehyd; 2,4-Dimethoxybenzylamine; With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 2h;

CN-Phe-Leu-OMe; Cbz-Tyr(tBu)-Gly-Ile-OH; In methanol; at 20 ℃; for 24h;

DOI:10.1021/acs.orglett.7b01761

Reference yield:

CN-Phe-Leu-OMe (1112971-02-4) → cyclo(Tyr-Gly-Ile-Gly-Phe-Leu)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 2 h / 20 °C

1.2: 24 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 5 h / 0 °C

3.1: palladium on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr

4.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; dmap / dichloromethane; ethyl acetate / 12 h

5.1: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; palladium on activated carbon; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 1.1: |Ugi Condensation / 1.2: |Ugi Condensation;

DOI:10.1021/acs.orglett.7b01761

upstream raw materials:

N-formyl-(S)-phenylalanyl-(S)-leucine methyl ester