benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

Base Information

Chemical Name:benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate
CAS No.:1027520-63-3
Molecular Formula:C₂₆H₃₃NO₄Si
Molecular Weight:451.638
Hs Code.:

Synonyms:benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

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Chemical Property of benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

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Technology Process of benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

There total 5 articles about benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35677-89-5
benzyl (3S)-2-oxotetrahydro-3-furanylcarbamate

: 1027520-63-3
benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / trimethylaluminum; pyridine / CH₂Cl₂; hexane / 72 h / 20 °C

2: 84 percent / imidazole / dimethylformamide / 16 h / 20 °C

3: tetrahydrofuran / 5 h / -78 - 0 °C

With pyridine; 1H-imidazole; trimethylaluminum; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo011062q

Reference yield:

: 403832-13-3
benzyl (1S)-3-hydroxy-1-{[methoxy(methyl)amino]carbonyl}propylcarbamate

: 1027520-63-3
benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 5 h / -78 - 0 °C

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo011062q

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1027520-63-3
benzyl (1S)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-4-phenyl-3-butynylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 5 h / -78 - 0 °C

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo011062q