2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

Base Information

Chemical Name:2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine
CAS No.:628316-85-8
Molecular Formula:C₃₉H₄₅N₅O₉
Molecular Weight:727.814
Hs Code.:

Synonyms:2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

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Chemical Property of 2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

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Technology Process of 2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

There total 4 articles about 2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 628316-84-7
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

: 628316-85-8
2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

Guidance literature:: With methanol; sodium methylate; at 20 ℃; for 0.5h;
DOI:10.1021/jm030883f

Reference yield:

: 87-42-3
6-chloropurine

: 628316-85-8
2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / DBU; TMSOTf / acetonitrile / 1 h / 60 °C

2: 96 percent / Et₃N / CH₂Cl₂; ethanol / 2 h / 60 °C

3: 57 percent / NaOMe; MeOH / 0.5 h / 20 °C

With methanol; trimethylsilyl trifluoromethanesulfonate; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; acetonitrile; 1: modified Vorbrueggen condensation;
DOI:10.1021/jm030883f

Reference yield:

: 197644-83-0
1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside

: 628316-85-8
2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-(dimethylamino)-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / DBU; TMSOTf / acetonitrile / 1 h / 60 °C

2: 96 percent / Et₃N / CH₂Cl₂; ethanol / 2 h / 60 °C

3: 57 percent / NaOMe; MeOH / 0.5 h / 20 °C

With methanol; trimethylsilyl trifluoromethanesulfonate; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; acetonitrile; 1: modified Vorbrueggen condensation;
DOI:10.1021/jm030883f