(5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile

Base Information

• Chemical Name: (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile
• CAS No.: 200343-04-0
• Molecular Formula: C₁₇H₁₅N₃OS
• Molecular Weight: 309.392
• Mol file: 200343-04-0.mol

Synonyms:(5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile

Chemical Property of (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile

There total 2 articles about (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

p-methoxybenzylnitrile (104-47-2) + 4-Bromo-5,6-dimethyl-thieno[2,3-d]pyrimidine (200342-35-4) → (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile (200343-04-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 130 ℃; for 0.5h;

DOI:10.3987/COM-97-7914

Reference yield:

4-amino-5,6-dimethylthieno[2,3-d]pyrimidine (4994-89-2) → (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile (200343-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / isoamyl nitrite, CH₂Br₂ / 1 h / 80 - 85 °C

2: 74 percent / 60percent sodium hydride in oil / dimethylformamide / 0.5 h / 130 °C

With sodium hydride; 1,1-dibromomethane; isopentyl nitrite; In N,N-dimethyl-formamide;

DOI:10.3987/COM-97-7914

Reference yield: 96.0%

(5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-acetonitrile (200343-04-0) → (5,6-Dimethyl-thieno[2,3-d]pyrimidin-4-yl)-(4-methoxy-phenyl)-methanone

Guidance literature:

With oxygen; sodium hydride; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.3987/COM-97-7914

upstream raw materials:

p-methoxybenzylnitrile

4-Bromo-5,6-dimethyl-thieno[2,3-d]pyrimidine

4-amino-5,6-dimethylthieno[2,3-d]pyrimidine