2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine

Base Information

• Chemical Name: 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine
• CAS No.: 1283097-01-7
• Molecular Formula: C₁₆H₁₂F₃N₃
• Molecular Weight: 303.287
• Mol file: 1283097-01-7.mol

Synonyms:2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine

Chemical Property of 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine

There total 4 articles about 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylacetophenone dimethyl acetal (53578-01-1) → 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine (1283097-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: methanol / 2 h / 0 °C

3: methanol / 24 h / Reflux

With pyridine; In methanol;

DOI:10.3390/molecules16042817

Reference yield:

2.6-diaminopyridine (141-86-6) + 1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one (187812-31-3) → 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine (1283097-01-7)

Guidance literature:

In methanol; at 0 ℃; for 24h; regioselective reaction; Reflux;

DOI:10.1016/j.tetlet.2016.09.068

Reference yield:

C16H14F3N3O → 2-amino-5-trifluoromethyl-7-(4-methylphenyl)-1,8-naphthyridine (1283097-01-7)

Guidance literature:

In methanol; for 24h; Reflux;

DOI:10.3390/molecules16042817

upstream raw materials:

4-methylacetophenone dimethyl acetal

1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one

2.6-diaminopyridine