2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde

Base Information

Chemical Name:2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde
CAS No.:279251-11-5
Molecular Formula:C₁₀H₇N₃O₃
Molecular Weight:217.184
Hs Code.:
DSSTox Substance ID:DTXSID201241627

Synonyms:279251-11-5;SCHEMBL10589328;DTXSID201241627;AKOS013432482;2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde

Suppliers and Price of 2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:217.04874109
Heavy Atom Count:16
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC=C(N2)C=O)[N+](=O)[O-]

Technology Process of 2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde

There total 2 articles about 2-(4-Nitrophenyl)-1H-imidazole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 279250-92-9
2-(4-nitrophenyl)-4-cyano-1H-imidazole

: 279251-11-5
2-(4-nitrophenyl)-1H-4-imidazolcarbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 - 0 ℃;
DOI:10.1021/jm991154w

Reference yield:

: 33469-09-9
2-(4-nitrophenyl)-4-trifluoromethyl-1H-imidazole

: 279251-11-5
2-(4-nitrophenyl)-1H-4-imidazolcarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / aq. NH₃ / methanol / 24 h / 60 °C

2: 36 percent / DIBALH / tetrahydrofuran; toluene / -78 - 0 °C

With ammonium hydroxide; diisobutylaluminium hydride; In tetrahydrofuran; methanol; toluene; 1: Substitution / 2: Reduction;
DOI:10.1021/jm991154w