2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester
• CAS No.: 35768-28-6
• Molecular Formula: C₁₂H₁₀N₂O₅
• Molecular Weight: 262.222
• Mol file: 35768-28-6.mol

Synonyms:2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester

Chemical Property of 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester

There total 2 articles about 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-cyano-3-(4-nitrophenyl)-2-propenoic acid ethyl ester (2017-89-2,2286-33-1,96238-12-9) → 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester (35768-28-6)

Guidance literature:

With calcium hypochlorite; In neat (no solvent); at 20 ℃; for 2h; Milling;

DOI:10.1016/j.tetlet.2018.05.077

Reference yield:

→ 2-cyano-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester (35768-28-6)

Guidance literature:

Ethyl-α-cyano-β-(p-nitrophenyl)acrylat, H2O2;

DOI:10.1246/bcsj.44.3468

Reference yield: 80.0%

(2R,3S)-2-Cyano-3-(4-nitro-phenyl)-oxirane-2-carboxylic acid ethyl ester (35768-28-6,104165-32-4) → (2S,3S)-2-Hydroxymethyl-3-(4-nitro-phenyl)-oxirane-2-carbonitrile (104165-25-5,116204-24-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81701-4

upstream raw materials:

2-cyano-3-(4-nitrophenyl)-2-propenoic acid ethyl ester

Downstream raw materials:

(2S,3S)-2-Hydroxymethyl-3-(4-nitro-phenyl)-oxirane-2-carbonitrile