(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester
CAS No.:197895-11-7
Molecular Formula:C₂₂H₂₄N₄O₃
Molecular Weight:392.458
Hs Code.:

(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-<i>hi</i>]indol-3-yl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Suppliers and Price of (9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of (9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

There total 6 articles about (9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197895-10-6
(9-nitro-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

: 197895-11-7
(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; 5percent Ru/C; In methanol; at 80 ℃; for 6h; under 6000.6 Torr;
DOI:10.1021/jm000315p

Reference yield:

: 126149-54-0
(RS)-3-amino-5-phenyl-3,4,6,7,-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one

: 197895-11-7
(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-acetyl-L-phenylalanine / ethyl acetate / 0.08 h / Heating

1.2: 99 percent / 1 N NaOH / CH₂Cl₂ / 5 °C

2.1: 74 percent / KNO₃; H₂SO₄ / 0.67 h / 5 °C

3.1: tetrahydrofuran / 0 - 20 °C

4.1: H₂ / 5percent Ru/C / methanol / 6 h / 80 °C / 6000.6 Torr

With sulfuric acid; (S)-2-acetylamino-3-phenylpropanoic acid; hydrogen; potassium nitrate; 5percent Ru/C; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm000315p

Reference yield:

: 126252-50-4
(3R)-3-amino-5-phenyl-3,4,6,7-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one

: 197895-11-7
(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / KNO₃; H₂SO₄ / 0.67 h / 5 °C

2: tetrahydrofuran / 0 - 20 °C

3: H₂ / 5percent Ru/C / methanol / 6 h / 80 °C / 6000.6 Torr

With sulfuric acid; hydrogen; potassium nitrate; 5percent Ru/C; In tetrahydrofuran; methanol;
DOI:10.1021/jm000315p