126149-54-0Relevant academic research and scientific papers
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of potent, selective phosphodiesterase type 4 inhibitors
Burnouf,Auclair,Avenel,Bertin,Bigot,Calvet,Chan,Durand,Fasquelle,Féru,Gilbertsen,Jacobelli,Kebsi,Lallier,Maignel,Martin,Milano,Ouagued,Pascal,Pruniaux,Puaud,Rocher,Terrasse,Wrigglesworth,Doherty
, p. 4850 - 4867 (2007/10/03)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submicromo
Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds
Satoh,Matsuo,Sogabe,Itoh,Tada,Kinoshita,Yoshida,Takaya
, p. 2071 - 2083 (2007/10/02)
We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of 125I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK
Tricyclic compounds
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, (2008/06/13)
Tricyclo benzodiazepines are cholecystokinin antagonists.
