(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one
CAS No.:1223427-38-0
Molecular Formula:C₂₃H₂₇FN₄O₄
Molecular Weight:442.49
Hs Code.:

Synonyms:(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

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Chemical Property of (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

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Technology Process of (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

There total 6 articles about (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13061-96-6
dihydroxy-methyl-borane

: 1223427-36-8
(R)-3-{4-[4-(3,5-dichloropyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

: 1223427-38-0
(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

Guidance literature:: With potassium fluoride; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 1223432-71-0
(R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)-3-fluoro-benzoyl]piperazine-1-carboxylic acid tert-butyl ester

: 1223427-38-0
(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / 1,2-dimethoxyethane / 20 °C

1.2: Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice

3.1: hydrogenchloride / ethyl acetate / 20 °C

3.2: Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

5.1: potassium fluoride / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; potassium fluoride; water; sodium hydride; potassium carbonate; sodium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1223432-73-2
(R)-4-[3-fluoro-4-(4-hydroxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester

: 1223427-38-0
(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice

2.1: hydrogenchloride / ethyl acetate / 20 °C

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4.1: potassium fluoride / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; potassium fluoride; sodium hydride; potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; mineral oil;