3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

Base Information

Chemical Name:3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride
CAS No.:1422570-01-1
Molecular Formula:C₁₄H₇Br₂FN₂O₄S
Molecular Weight:478.093
Hs Code.:

Synonyms:3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

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Chemical Property of 3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

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Technology Process of 3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

There total 9 articles about 3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1422570-82-8
4-(5-(3,5-dibromo-4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

: 1422570-01-1
3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ja311729d

Reference yield:

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 1422570-01-1
3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydrogen bifluoride / 1,4-dioxane; water / 0.5 h / 20 °C / Inert atmosphere

2: thionyl chloride / 2 h / 75 °C / Inert atmosphere

3: triethylamine / dichloromethane; dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

4: p-toluenesulfonyl chloride; dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; potassium hydrogen bifluoride; boron tribromide; triethylamine; p-toluenesulfonyl chloride; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/ja311729d

Reference yield:

: 402-55-1
4-fluorosulfonylbenzoyl chloride

: 1422570-01-1
3-(5-(3,5-dibromo-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane; dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

2: p-toluenesulfonyl chloride; dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With dmap; boron tribromide; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja311729d