tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate

Base Information

• Chemical Name: tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate
• CAS No.: 1408282-75-6
• Molecular Formula: C₁₆H₂₂FNO₅S
• Molecular Weight: 359.419
• Mol file: 1408282-75-6.mol

Synonyms:tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate

Chemical Property of tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate

There total 1 articles about tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

4-methoxy-phenyl-sulphonyl chloride (98-68-0) + tert-butyl (R)-(+)-2-amino-4-fluoropent-4-enoate (247122-85-6) → tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate (1408282-75-6)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 48h;

DOI:10.1016/j.bmc.2015.03.078

Reference yield: 58.0%

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate (1408282-75-6) + 3-chloromethylpyridinium chloride (6959-48-4) → tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoate (1408282-85-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2015.03.078

Reference yield:

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-γ-fluoro-α-aminopent-4-enoate (1408282-75-6) → (R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoic acid (1408282-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Sealed tube

With potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.03.078

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

tert-butyl (R)-(+)-2-amino-4-fluoropent-4-enoate

Downstream raw materials:

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoate

(R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoic acid

O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enehydroxamate

(R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enehydroxamic acid