2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

Base Information

Chemical Name:2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide
CAS No.:1012054-52-2
Molecular Formula:C₁₇H₁₄ClFN₄O₄
Molecular Weight:392.774
Hs Code.:

Synonyms:2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

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Chemical Property of 2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

Chemical Property:

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Technology Process of 2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

There total 8 articles about 2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1012057-13-4
thyl 2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)acetate

: 1012054-52-2
2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

Guidance literature:: With hydroxylamine; at 0 - 20 ℃; for 0.166667h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1012054-52-2
2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 3 h / Heating / reflux

2: methanol; lithium hydroxide; water / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

4: hydroxylamine / methanol / 0.17 h / 0 - 20 °C

With methanol; lithium hydroxide; water; hydroxylamine; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1012054-52-2
2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 3 h / Heating / reflux

2: isopropyl alcohol / 3 h / Heating / reflux

3: methanol; lithium hydroxide; water / 0.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

5: hydroxylamine / methanol / 0.17 h / 0 - 20 °C

With methanol; lithium hydroxide; water; hydroxylamine; potassium carbonate; trichlorophosphate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;