ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

Base Information

Chemical Name:ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate
CAS No.:1307813-78-0
Molecular Formula:C₃₂H₃₂F₃N₃O₅
Molecular Weight:595.618
Hs Code.:

ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

Synonyms:ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

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Chemical Property of ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

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Technology Process of ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

There total 13 articles about ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1307813-77-9
8-methyl-7-(oxiran-2-yl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1307813-78-0
ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

Guidance literature:: With dmap; In 1,4-dioxane; isopropyl alcohol; at 50 ℃; for 24h;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307813-78-0
ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0 °C

5.2: 0.58 h / 0 °C

6.1: boron tribromide / dichloromethane / 0 - 20 °C

7.1: pyridine / 0 - 20 °C

8.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere

10.1: dmap / isopropyl alcohol; 1,4-dioxane / 24 h / 50 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; N-iodo-succinimide; lithium hydroxide monohydrate; boron tribromide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium chloride; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 536-74-3
phenylacetylene

: 1307813-78-0
ethyl (3S)-1-(2-hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 0 °C

6.2: 0.58 h / 0 °C

7.1: boron tribromide / dichloromethane / 0 - 20 °C

8.1: pyridine / 0 - 20 °C

9.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C

10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere

11.1: dmap / isopropyl alcohol; 1,4-dioxane / 24 h / 50 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; N-iodo-succinimide; lithium hydroxide monohydrate; boron tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium chloride; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;