(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

Base Information

Chemical Name:(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one
CAS No.:1266785-34-5
Molecular Formula:C₂₆H₂₅FN₂O₂
Molecular Weight:416.495
Hs Code.:

Synonyms:(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

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Technology Process of (R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

There total 7 articles about (R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1013-88-3
Benzophenone imine

: 1266785-30-1
(R)-5-(5-bromo-2-fluoro-phenyl)-5,6,6-trimethyl-morpholin-3-one

: 1266785-34-5
(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

Guidance literature:: With sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 105 ℃; for 20h; Inert atmosphere; sealed tube;

Reference yield:

: 668969-68-4
ethyl 2-(5-bromo-2-fluorophenyl)-2-oxoacetate

: 1266785-34-5
(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 3.5 h / 20 - 70 °C

2.1: tetrahydrofuran; 2-methyltetrahydrofuran / -70 - 20 °C

2.2: Cooling

3.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 0 - 20 °C

4.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 0 °C

5.1: potassium pentanolate / toluene / 1.25 h / 23 °C

6.1: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 20 h / 105 °C / Inert atmosphere; sealed tube

With hydrogenchloride; titanium(IV) tetraethanolate; sodium hydrogencarbonate; potassium pentanolate; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1266785-28-7
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1,2-dimethyl-propyl]-2-chloro-acetamide

: 1266785-34-5
(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5,6,6-trimethyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium pentanolate / toluene / 1.25 h / 23 °C

2: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 20 h / 105 °C / Inert atmosphere; sealed tube

With potassium pentanolate; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene;