4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

Base Information

Chemical Name:4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile
CAS No.:300627-64-9
Molecular Formula:C₁₆H₁₉IN₄OS
Molecular Weight:442.324
Hs Code.:

Synonyms:4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

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Chemical Property of 4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

Chemical Property:

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Technology Process of 4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

There total 7 articles about 4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2-((4-hydroxybutyl)amino)-2-methylpropanenitrile

: 300627-53-6
2-iodo-4-isothiocyanatobenzonitrile

: 300627-64-9
4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h; Heating;
DOI:10.1021/jm000163y

Reference yield:

: 89677-75-8
2-iodo-4-nitrobenzamide

: 300627-64-9
4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / SOCl₂ / 3 h / Heating

2: 98 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

3: tetrahydrofuran; H₂O / 3 h / 20 °C

4: 64 percent / Et₃N / tetrahydrofuran / 1 h / Heating

With thionyl chloride; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; water; 1: Dehydration / 2: Reduction / 3: Condensation / 4: Condensation;
DOI:10.1021/jm000163y

Reference yield:

: 89459-38-1
4-nitro-2-iodobenzoic acid

: 300627-64-9
4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 3 h / 60 °C

2: conc. aq. NH₃ / 20 °C

3: 80 percent / SOCl₂ / 3 h / Heating

4: 98 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

5: tetrahydrofuran; H₂O / 3 h / 20 °C

6: 64 percent / Et₃N / tetrahydrofuran / 1 h / Heating

With ammonium hydroxide; thionyl chloride; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; water; 1: Chlorination / 2: Acylation / 3: Dehydration / 4: Reduction / 5: Condensation / 6: Condensation;
DOI:10.1021/jm000163y