N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide

Base Information

• Chemical Name: N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide
• CAS No.: 1131192-38-5
• Molecular Formula: C₂₀H₂₁IN₂O₃
• Molecular Weight: 464.303
• Mol file: 1131192-38-5.mol

Synonyms:N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide

Chemical Property of N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide

There total 1 articles about N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-iodo-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide (1131192-58-9) + benzoyl chloride (98-88-4) → N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide (1131192-38-5)

Guidance literature:

2-iodo-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

benzoyl chloride; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1016/j.tetasy.2008.11.021

Reference yield: 77.0%

N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide (1131192-38-5) → 3-hydroxy-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one (604767-00-2)

Guidance literature:

N-(2-iodobenzoyl)-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)benzamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -30 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexane; water;

DOI:10.1016/j.tetasy.2008.11.021

upstream raw materials:

2-iodo-N-((S)-2-(2-methoxymethylpyrrolidin-1-yl))benzamide

benzoyl chloride

Downstream raw materials:

3-hydroxy-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one