VPC₁₄₃v47

Base Information

• Chemical Name: VPC₁₄₃v47
• CAS No.: 1266665-55-7
• Molecular Formula: C₂₇H₄₃N₃O*ClH
• Molecular Weight: 462.119
• Mol file: 1266665-55-7.mol

Synonyms:VPC₁₄₃v47

Chemical Property of VPC₁₄₃v47

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of VPC₁₄₃v47

There total 13 articles about VPC₁₄₃v47 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile (1307310-18-4) → VPC143v47 (1266665-55-7)

Guidance literature:

(S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile; With sodium methylate; In methanol; at 20 - 50 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In methanol; at 50 ℃; Inert atmosphere;

DOI:10.1021/jm2001053

Reference yield:

4-(9-cyclohexylnonyl)benzaldehyde (1307310-17-3) → VPC143v47 (1266665-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; 1.1: Pinnick oxidation;

DOI:10.1021/jm2001053

Reference yield:

non-8-en-1-ylcyclohexane (183598-36-9) → VPC143v47 (1266665-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C

1.2: 16 h

2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

4.2: 50 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; 1.2: Suzuki coupling / 2.1: Pinnick oxidation;

DOI:10.1021/jm2001053

upstream raw materials:

(S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile

C₂₂H₃₄O₂

non-8-en-1-ylcyclohexane

4-(9-cyclohexylnonyl)benzaldehyde