3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

Base Information

Chemical Name:3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester
CAS No.:1256337-00-4
Molecular Formula:C₃₆H₅₀BN₃O₈
Molecular Weight:663.619
Hs Code.:

3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

Synonyms:3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

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Chemical Property of 3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

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Technology Process of 3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

There total 8 articles about 3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887580-70-3
2-[2-(tert-butoxycarbonylamino)pyridin-4-yl]acetic acid

: 1256336-53-4
3-[(2R)-2-[bis(trimethylsilyl)amino]-2-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]ethyl]-2-methoxy-benzoic acid 1,1-dimethylethyl ester

: 1256337-00-4
3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

Guidance literature:: 2-[2-(tert-butoxycarbonylamino)pyridin-4-yl]acetic acid; With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 1h;

3-[(2R)-2-[bis(trimethylsilyl)amino]-2-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]ethyl]-2-methoxy-benzoic acid 1,1-dimethylethyl ester; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 913836-10-9
3-(dihydroxyboranyl)-2-methoxybenzoic acid

: 1256337-00-4
3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 1,4-dioxane; water / 18 h / 0 - 20 °C / Sealed tube

2.1: tetrahydrofuran / 1 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -100 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -100 °C / Inert atmosphere

4.2: -100 - 0 °C / Inert atmosphere

4.3: -78 - 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C

5.2: 0 - 20 °C

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;

Reference yield:

: 3678-62-4
2-chloro-4-picoline

: 1256337-00-4
3-(2-((2-tert-butoxycarbonylamino-pyridin-4-ylacetyl)-amino)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl)-2-methoxy-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: -78 - 20 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 20 h / Inert atmosphere; Heating; Reflux

3.1: methanol; water; sodium hydroxide / 1.5 h / Reflux

3.2: pH 4 - 5

4.1: 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C

4.2: 0 - 20 °C

With 4-methyl-morpholine; methanol; 1-hydroxy-pyrrolidine-2,5-dione; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; hexane; dichloromethane;