(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

Base Information

Chemical Name:(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one
CAS No.:405522-29-4
Molecular Formula:C₁₈H₁₆BrNO₂
Molecular Weight:358.235
Hs Code.:

Synonyms:(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

Chemical Property:

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Technology Process of (3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

There total 3 articles about (3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 6340-79-0
4-oxo-4-(4-bromophenyl)butanoic acid

: 20989-17-7
(2S)-2-phenylglycinol

: 405522-29-4
(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

Guidance literature:: In toluene; for 16h; Reflux;
DOI:10.1002/cjoc.201300363

Reference yield:

: 2(S)-2-amino-2-phenylethanol

: 6340-79-0
4-oxo-4-(4-bromophenyl)butanoic acid

: 104-15-4
toluene-4-sulfonic acid

: 405522-29-4
(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

Guidance literature:: In toluene;

Reference yield:

: 30913-86-1
4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester

: 405522-29-4
(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

2: toluene / 16 h / Reflux

With water; lithium hydroxide; In tetrahydrofuran; toluene;
DOI:10.1002/cjoc.201300363