6340-79-0

Usage

Chemical Properties

white to light beige shiny crystalline flakes

InChI:InChI=1/C10H9BrO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)/p-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-86-1 bromobenzene 
• 35513-39-4 β-(4-bromobenzoyl)acrylic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 51765-77-6 4-(4-bromo-phenyl)-4-oxo-butyronitrile 
• 851108-42-4 4-(4-bromophenyl)-4-oxobutanamide 
• 861777-41-5 4-bromo-3-(4-bromo-benzoyl)-4-phenyl-butyric acid methyl ester 
• 30913-86-1 4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester 
• 856099-40-6 5-(4-bromo-phenyl)-5-hydroxy-1-methyl-pyrrolidin-2-one 
• 7664-93-9 sulfuric acid 
• 7477-66-9 4-oxo-4-(4-bromo-phenyl)-trans-crotonic acid-chloride 
• 861799-19-1 [1-(α-bromo-benzyl)-2-(4-bromo-phenyl)-2-oxo-ethyl]-malonic acid 
• 99-90-1 para-bromoacetophenone 
• 81008-11-9 C₁₀H₉BrO₄ 

Downstream Products

• 30913-86-1 4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester 
• 60112-48-3 5-(p-bromophenyl)-β,γ-butenolide 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 1821-12-1 4-Phenylbutyric acid 
• 134949-94-3 (E)-5,5'-bis-(4-bromo-phenyl)-[3,3']bifurylidene-2,2'-dione 
• 70324-97-9 4-(4-bromo-3-nitrophenyl)-4-oxobutanoic acid 
• 69099-72-5 4-(4-bromobenzoyl)dihydrofuran-2(3H)-one 
• 76593-30-1 3-(4-bromobenzoyl)-3-butenoic acid 
• 76593-33-4 4-(4-Bromo-benzoyl)-4-hydroxymethyl-dihydro-furan-2-one 
• 124-38-9 carbon dioxide 
• 586-76-5 4-Bromobenzoic acid 
• 35158-41-9 3-bromo-4-(4-bromophenyl)-4-oxobutanoic acid 
• 1026189-07-0 C₁₃H₁₃BrO₅ 
• 97728-47-7 dimethyl 2-(4-bromophenyl)succinate 

Relevant academic research and scientific papers

Pd Nanoparticles Embedded Into MOF-808: Synthesis, Structural Characteristics, and Catalyst Properties for the Suzuki–Miyaura Coupling Reaction

Abstract: A heterogeneous single-site catalyst Pd@MOF-808 was successfully synthesized by water-based, green synthesis procedure. The catalytic experiments exhibited the Pd@MOF-808 promoted efficiently the Suzuki–Miyaura coupling reaction without the assistance of organic phosphine ligands at atmospheric pressure conditions. The catalyst also could be applied in the gram-scale synthesis of industrially anti-inflanmatory analgestic Fenbufen. Graphic Abstract: [Figure not available: see fulltext.]

In silico designing, in vitro and in vivo evaluation of potential PPAR-γ agonists derived from aryl propionic acid scaffold

Attributed to several side effects, especially on hepatic tissues and body weight, there is always an urge of innovation and upgrading in already existing medication being used in maintaining diabetic condition. Therefore, in the present work, forty-eight molecules derived from arylpropionic acid scaffold were synthesized and their evaluation against diabetes was carried out. The synthesis of these molecules attributed to excellent dock score displayed by all the structures performed against PPAR-γ receptor site. Subsequently, all the derivatives were primarily deduced for their antidiabetic potential by OGTT. The compounds that showed significant antidiabetic activity in OGT Test and also exhibited high dock scores were assessed further by in vitro PPAR transactivation assay to assure analogy between in vivo and in vitro studies. The antidiabetic activity of these active compounds was then evaluated on STZ induced diabetic model in vivo. The most active compounds were scrutinized for its effect on PPAR-γ gene expression and hepatotoxic effect. Finally, it was recapitulated that these derivatives can provide a new prospect towards the development of antidiabetic agents with fewer side effects.

Tetrakis(4-formylphenyl) ferrocene and preparation method and application thereof

The invention relates to the technical field of material synthesis, in particular to tetrakis(4-formylphenyl) ferrocene as well as a preparation method and application thereof. The preparation method comprises the following steps: in a nitrogen atmosphere, dropwise adding n-butyllithium into a tetrahydrofuran solution in which tetrakis(4-X-phenyl) ferrocene is dissolved, controlling the temperature and stirring, with the X being Br or I; then dropwise adding N,N-dimethylformamide, and after the N,N-dimethylformamide is completely added, controlling the temperature and stirring; transferring the reaction liquid into diluted hydrochloric acid, and stirring to separate out a solid; and filtering the separated solid, washing with methanol, re-dissolving the washed solid with ethyl acetate, and carrying out reduced pressure rotary evaporation on the obtained solution. The prepared tetrakis(4-formylphenyl) ferrocene can be condensed with aromatic amine to form an imine bond, so that a ferrocene structure is combined with a COFs structure to form a novel MCOFs material, the novel MCOFs material has excellent physical and chemical properties of ferrocene, a large number of metal active sites can be provided, and the structure is stable.

Iridium-Catalyzed Asymmetric Hydrogenation of ?- A nd ?-Ketoacids for Enantioselective Synthesis of ?- A nd ?-Lactones

A highly efficient asymmetric hydrogenation of ?- A nd ?-ketoacids was developed by using a chiral spiro iridium catalyst (S)-1a, affording the optically active ?- A nd ?-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

Pyridazinone analogues have been known to be potential candidates for anticonvulsant agents. We have identified several pyridazinone-based anticonvulsant agents. As a continuation to our previous research, a series of hybrid pyridazinone-thiazole connected through amide linkage were designed and synthesized. Among these, compound SP-5F demonstrated significant anticonvulsant activity with median effective dose of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Molecular docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of SP-5F.

Asymmetric hydrogenation reaction γ - or δ - ketonato compound (by machine translation)

The invention relates to the field, of organic chemistry, specifically γ - or δ - keto acid compound asymmetric hydrogenation reaction, reaction formula as follows : Wherein R is H,C. 1 - C6 An alkyl or halogen, is R 1 - 5 in number of substituents . wherein n is 1 or 2;Cat. is a chiral spiro pyrimidyl phosphine ligand iridium complex . and γ - or δ - keto acid compound is subjected to an internal esterification reaction to further prepare a lactone compound. (by machine translation)

One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodology was applied on levulinic acid and derivatives, one of the biosourced platform chemicals.

Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C?O Bond Formation

A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C?O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl-substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed-etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.

Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines

By employing triethylamine as a catalyst, [3?+?2] coupling-elimination cascade of α,α-dicyanoolefins with quinone monoimines was realized. The reactions afforded various novel pterocarpen analogues with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed.

Visible-light-induced oxidation/[3 + 2] cycloaddition/oxidative aromatization to construct benzo[ a]carbazoles from 1,2,3,4-tetrahydronaphthalene and arylhydrazine hydrochlorides

An efficient synthesis of benzo[a]carbazoles via visible-light-induced tandem oxidation/[3 + 2] cycloaddition/oxidative aromatization reactions was reported. The benzylic C(sp3)-H of tetrahydronaphthalene was activated through visible-light photoredox catalyst with oxygen as the clean oxidant under mild reaction conditions. This protocol proceeds efficiently with broad substrate scope, and the mechanism study was performed.