9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

Base Information

Chemical Name:9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid
CAS No.:1246453-64-4
Molecular Formula:C₂₃H₂₄ClNO₄
Molecular Weight:413.901
Hs Code.:

Synonyms:9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

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Chemical Property of 9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

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Technology Process of 9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

There total 11 articles about 9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1246453-63-3
9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid ethyl ester

: 1246453-64-4
9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 80 ℃; for 18h;
DOI:10.1002/cmdc.201900023

Reference yield:

: 1246453-62-2
3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

: 1246453-64-4
9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: zinc chloride / ethyl acetate; diethyl ether

2: sodium hydroxide / ethanol; water

With sodium hydroxide; zinc chloride; In diethyl ether; ethanol; water; ethyl acetate;

Reference yield:

: 1274863-78-3
2-benzyloxy-N-(2-chloro-5-methoxy-phenyl)acetamide

: 1246453-64-4
9-(2-benzyloxy-ethyl)-8-chloro-5-methoxy-2,3,4,9,-tetrahydro-1H-carbazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -40 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: zinc(II) chloride / diethyl ether / 125.5 h / Inert atmosphere; Reflux

4.1: sodium hydroxide / water; ethanol / 18 h / 80 °C

With lithium aluminium tetrahydride; potassium hexamethylsilazane; sodium hydroxide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; water; toluene;