3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

Base Information

Chemical Name:3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester
CAS No.:1246453-62-2
Molecular Formula:C₂₅H₃₀ClNO₅
Molecular Weight:459.97
Hs Code.:

Synonyms:3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

There total 8 articles about 3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246453-61-1
(2-benzyloxy-ethyl)-(2-chloro-5-methoxyphenyl)amine

: 145222-30-6
3-bromo-2-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

: 1246453-62-2
3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

Guidance literature:: (2-benzyloxy-ethyl)-(2-chloro-5-methoxyphenyl)amine; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -40 ℃; for 0.5h; Inert atmosphere;

3-bromo-2-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester; In tetrahydrofuran; toluene; at 20 ℃; for 1.5h;

Reference yield:

aqueous potassium carbonate: aqueous potassium carbonate

: 1246453-61-1
(2-benzyloxy-ethyl)-(2-chloro-5-methoxyphenyl)amine

: 145222-30-6
3-bromo-2-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

: 1246453-62-2
3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; methanol; ethyl acetate; toluene;

Reference yield:

: 1274863-78-3
2-benzyloxy-N-(2-chloro-5-methoxy-phenyl)acetamide

: 1246453-62-2
3-[(2-Benzyloxy-ethyl)-(2-chloro-5-methoxy-phenyl)-amino]-2-hydroxy-cyclohex-1-ene carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -40 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

With lithium aluminium tetrahydride; potassium hexamethylsilazane; In tetrahydrofuran; toluene;