(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Base Information

Chemical Name:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate
CAS No.:153993-93-2
Molecular Formula:C₃₂H₃₇FO₃
Molecular Weight:488.642
Hs Code.:

Synonyms:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Suppliers and Price of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

There total 7 articles about (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4654-39-1
4-bromophenethanol

: 153993-93-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / CH₂Cl₂ / 2 h / 0 °C

2: Me₄NFHF / acetonitrile / 1 h / Ambient temperature

3: 1.) Mg, I₂ / 1.) THF, sonication, 2.) THF, a.) -78 deg C, 40 min, b.) 1 h

4: 2N aq. NaOH / 0.5 h

5: Cl₂CHOCH₃ / CH₂Cl₂ / 2 h / Heating

6: Et₃N / CH₂Cl₂ / 1 h / 0 °C

7: tetrahydrofuran / 4 h

With pyridine; sodium hydroxide; Dichloromethyl methyl ether; iodine; magnesium; tetramethylammonium hydrogen difluoride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

: 55153-09-8
1-bromo-4-(2-fluoroethyl)benzene

: 153993-93-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg, I₂ / 1.) THF, sonication, 2.) THF, a.) -78 deg C, 40 min, b.) 1 h

2: 2N aq. NaOH / 0.5 h

3: Cl₂CHOCH₃ / CH₂Cl₂ / 2 h / Heating

4: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: tetrahydrofuran / 4 h

With sodium hydroxide; Dichloromethyl methyl ether; iodine; magnesium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

: 153993-91-0
4-(2-fluoroethyl)benzoylformic acid

: 153993-93-2
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(R)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Guidance literature:: Multi-step reaction with 3 steps

1: Cl₂CHOCH₃ / CH₂Cl₂ / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: tetrahydrofuran / 4 h

With Dichloromethyl methyl ether; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(00)80069-5