2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Base Information

Chemical Name:2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol
CAS No.:1073186-77-2
Molecular Formula:C₂₃H₃₅N₃O₄S₂
Molecular Weight:481.681
Hs Code.:

Synonyms:2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

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Chemical Property of 2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

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Technology Process of 2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

There total 4 articles about 2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1073187-03-7
2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-3H-imidazole-4-carboxylic acid ethyl ester

: 1073186-77-2
2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: 2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-3H-imidazole-4-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium dihydrogenphosphate; water; In tetrahydrofuran;

Reference yield:

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1073186-77-2
2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

3.1: triethylamine / dichloromethane / 0.05 h

3.2: 2 h

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1073186-96-5
2,6-di-tert-butyl-4-(piperidin-4-ylsulfanyl)-phenol hydrochloride

: 1073186-77-2
2,6-di-tert-butyl-4-[1-(5-hydroxymethyl-1H-imidazole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.05 h

1.2: 2 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;