(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

Base Information

Chemical Name:(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione
CAS No.:89291-98-5
Molecular Formula:C₃₆H₄₂N₂O₈
Molecular Weight:630.738
Hs Code.:

(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

Synonyms:(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

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Chemical Property of (1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

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Technology Process of (1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

There total 9 articles about (1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89291-90-7
4-(tert-Butyl-diphenyl-silanyloxy)-3-((2S,5S)-1,4-dibenzyl-2,5-bis-benzyloxy-3,6-dioxo-piperazin-2-yl)-butyric acid methyl ester

: 89291-98-5
(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

Guidance literature:: Multi-step reaction with 9 steps

1: LiAlH₄ / tetrahydrofuran / -78 °C

2: NaBH₄ / methanol

3: imidazole

4: 88 percent / H₂, pyridine / 20 percent Pd-C / ethanol / 40 °C

5: Py

6: 80 percent / AcOH-H₂O / tetrahydrofuran

7: 84 percent / pyridinium tosylate / 1,2-dichloro-ethane / 80 °C

8: 1.) n-BuLi / 1.) -110 deg C, 2.) -78 deg C

9: n-Bu₄NF / tetrahydrofuran

With pyridine; 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)94158-3

Reference yield:

: 89291-92-9
(3S,6S)-1,4-Dibenzyl-3,6-bis-benzyloxy-3-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-propyl]-piperazine-2,5-dione

: 89291-98-5
(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole

2: 88 percent / H₂, pyridine / 20 percent Pd-C / ethanol / 40 °C

3: Py

4: 80 percent / AcOH-H₂O / tetrahydrofuran

5: 84 percent / pyridinium tosylate / 1,2-dichloro-ethane / 80 °C

6: 1.) n-BuLi / 1.) -110 deg C, 2.) -78 deg C

7: n-Bu₄NF / tetrahydrofuran

With pyridine; 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)94158-3

Reference yield:

: 89291-91-8
4-(tert-Butyl-diphenyl-silanyloxy)-3-((2S,5S)-1,4-dibenzyl-2,5-bis-benzyloxy-3,6-dioxo-piperazin-2-yl)-butyraldehyde

: 89291-98-5
(1S,6R)-7,9-Dibenzyl-6-benzyloxy-5-hydroxymethyl-1-[(S)-hydroxy-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

Guidance literature:: Multi-step reaction with 8 steps

1: NaBH₄ / methanol

2: imidazole

3: 88 percent / H₂, pyridine / 20 percent Pd-C / ethanol / 40 °C

4: Py

5: 80 percent / AcOH-H₂O / tetrahydrofuran

6: 84 percent / pyridinium tosylate / 1,2-dichloro-ethane / 80 °C

7: 1.) n-BuLi / 1.) -110 deg C, 2.) -78 deg C

8: n-Bu₄NF / tetrahydrofuran

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)94158-3