C₈H₃ClF₃IO

Base Information

• Chemical Name: C₈H₃ClF₃IO
• CAS No.: 1261586-48-4
• Molecular Formula: C₈H₃ClF₃IO
• Molecular Weight: 334.464
• Mol file: 1261586-48-4.mol

Synonyms:C₈H₃ClF₃IO

Chemical Property of C₈H₃ClF₃IO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₈H₃ClF₃IO

There total 2 articles about C₈H₃ClF₃IO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-4-(trifluoromethyl)benzoic acid (54507-44-7) → C8H3ClF3IO (1261586-48-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Inert atmosphere;

DOI:10.1039/c3ra42474j

Reference yield:

2-amino-4-trifluoromethylbenzoic acid (402-13-1) → C8H3ClF3IO (1261586-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 10 - 90 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; sodium nitrite; In dichloromethane; water;

DOI:10.1039/c3ra42474j

Reference yield: 71.0%

C8H3ClF3IO (1261586-48-4) + N-Boc-7-azabenzobicyclo[2.2.1]heptadiene (5176-28-3) → (1,4-dihydro-1,4-epiminonaphthalen-9-yl)(2-iodo-4-(trifluoromethyl)phenyl)methanone

Guidance literature:

N-Boc-7-azabenzobicyclo[2.2.1]heptadiene; With trimethylsilyl iodide; triethylamine; In dichloromethane; for 0.333333h; Reflux;

With methanol; In dichloromethane; at 0 ℃; for 0.166667h;

C₈H₃ClF₃IO; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.joc.6b00839

upstream raw materials:

2-amino-4-trifluoromethylbenzoic acid

2-iodo-4-(trifluoromethyl)benzoic acid

Downstream raw materials:

methyl 2-iodo-4-(trifluoromethyl)benzoate