1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose

Base Information

• Chemical Name: 1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose
• CAS No.: 849778-77-4
• Molecular Formula: C₃₀H₃₄N₅O₈P
• Molecular Weight: 623.602
• Mol file: 849778-77-4.mol

Synonyms:1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose

Chemical Property of 1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose

There total 10 articles about 1'α-(N⁶-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1α,2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose (849779-01-7) + 6-benzoylamino-9-trimethylsilylpurine (60855-35-8) → 1'α-(N6-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose (849778-77-4)

Guidance literature:

With tin(IV) chloride; In acetonitrile; at 20 ℃; for 4 - 5h;

Reference yield: 83.0%

C25H31O9P → 1'α-(N6-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose (849778-77-4)

Guidance literature:

With tin(IV) chloride; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1021/ja043045z

Reference yield: 80.0%

(diisopropoxyphosphoryl)methyl trifluoromethanesulfonate (134963-85-2) + N6-benzoyl-9-(2′-O-benzoyl-α-L-threofuranosyl)adenine (1446785-56-3) → 1'α-(N6-benzoyladenin-9-yl)-2'-O-benzoyl-3'-O-diisopropyl-phosphonomethyl-L-threose (849778-77-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at -5 - 0 ℃; for 0.25h;

DOI:10.1021/acs.jmedchem.6b01260

upstream raw materials:

1α,2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

6-benzoylamino-9-trimethylsilylpurine

(diisopropoxyphosphoryl)methyl trifluoromethanesulfonate

N⁶-benzoyl-9-(2′-O-benzoyl-α-L-threofuranosyl)adenine

Downstream raw materials:

1-(adenin-9-yl)-2-O-phenoxythiocarbonyl-3-O-(diisopropylphosphonomethyl)-L-threose