3-phenyl-3-(trimethylgermyl)propanoic acid

Base Information

Chemical Name:3-phenyl-3-(trimethylgermyl)propanoic acid
CAS No.:107790-76-1
Molecular Formula:C₁₂H₁₈GeO₂
Molecular Weight:266.864
Hs Code.:

Synonyms:3-phenyl-3-(trimethylgermyl)propanoic acid

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Chemical Property of 3-phenyl-3-(trimethylgermyl)propanoic acid

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-phenyl-3-(trimethylgermyl)propanoic acid

There total 2 articles about 3-phenyl-3-(trimethylgermyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3-phenyl-3-(trichlorogermyl)butanoic acid

: 75-16-1
methylmagnesium bromide

: 107790-76-1
3-phenyl-3-(trimethylgermyl)propanoic acid

Guidance literature:: In tetrahydrofuran; diethyl ether; under Ar, 4 equiv. of MeMgBr in Et2O was added to thf soln. of Ge-compd.below 5 °C over a period of 30 minwith stirring, temp. was allow ed to rise slowly, reflux for 3 h; mixt. was cooled in an ice-bath, hydrolysed with 20 % aq. HCl, extd. with CHCl3, extract was dried over MgSO4, chromy. (silica, CHCl3:hexane=1:3), elem. anal.;
DOI:10.1081/SIM-100002047

Reference yield:

: 3-phenyl-3-(trichlorogermyl)butanoic acid

: 107790-76-1
3-phenyl-3-(trimethylgermyl)propanoic acid

Guidance literature:: With methyl magnesium iodide; In diethyl ether; addn. of a soln. of MeMgI in abs. ether to a soln. of Ge-compd. in abs. ether (under N2) with stirring, refluxing for 30 min, pouring into dilute HCl; separating of ether layer, washing with water, drying over anhyd. MgSO4, evapn. to dryness in vac., distn. of residue, elem. anal.;
DOI:10.1016/0022-328X(90)87287-N

Reference yield: 80.0%

: 107790-76-1
3-phenyl-3-(trimethylgermyl)propanoic acid

: 38047-49-3
bis((trimethylsilyl)methyl)tin dichloride

: 355018-17-6
bis(trimethylsilylmethyl)bis(3-phenyl-3-trimethylgermyl)tin(IV) propionate

Guidance literature:: With Et₃N; In diethyl ether; chloroform; under Ar, 0.5 equiv. of Sn-compd. in Et2O was added to CHCl3 soln. of Ge-compd. and Et3N, reflux for 6 h; soln. was allowed to cool to room temp., solvent was removed in vac., extn. with CHCl3:hexane (1:3), elem. anal.;
DOI:10.1081/SIM-100002047