C₂₁H₂₀F₃NO₅

Base Information

Chemical Name:C₂₁H₂₀F₃NO₅
CAS No.:1301173-24-9
Molecular Formula:C₂₁H₂₀F₃NO₅
Molecular Weight:423.389
Hs Code.:

C<sub>21</sub>H<sub>20</sub>F<sub>3</sub>NO<sub>5</sub>

Synonyms:C₂₁H₂₀F₃NO₅

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₂₀F₃NO₅

Chemical Property:

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Technology Process of C₂₁H₂₀F₃NO₅

There total 5 articles about C₂₁H₂₀F₃NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301173-23-8
C₁₈H₁₆F₃NO₃

: 541-41-3
chloroformic acid ethyl ester

: 1301173-24-9
C₂₁H₂₀F₃NO₅

Guidance literature:: C₁₈H₁₆F₃NO₃; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.75h;

chloroformic acid ethyl ester; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;

Reference yield:

: 1186309-52-3
1,3-diethyl 2-(5-fluoropyridin-2-yl)propanedioate

: 1301173-24-9
C₂₁H₂₀F₃NO₅

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 50 - 60 °C

2.1: sodium hydroxide; water / 1 h / 100 °C

2.2: pH ~ 1 / Cooling with ice

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Cooling with salt-ice; Cooling with ice

3.2: 20 °C / Cooling with ice; Cooling with salt-ice

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

With water; sodium hydride; sodium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1301173-24-9
C₂₁H₂₀F₃NO₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; copper(l) iodide; 2-Picolinic acid / 1,4-dioxane / 100 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 50 - 60 °C

3.1: sodium hydroxide; water / 1 h / 100 °C

3.2: pH ~ 1 / Cooling with ice

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Cooling with salt-ice; Cooling with ice

4.2: 20 °C / Cooling with ice; Cooling with salt-ice

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 0 - 20 °C

5.2: 2 h / 0 - 20 °C

With 2-Picolinic acid; copper(l) iodide; water; sodium hydride; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;