3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate)

Base Information

• Chemical Name: 3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate)
• CAS No.: 78426-04-7
• Molecular Formula: C₂₄H₂₁Cl₂NO₃
• Molecular Weight: 442.342
• Mol file: 78426-04-7.mol

Synonyms:3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate)

Chemical Property of 3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate)

There total 1 articles about 3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2,6-Dichlorobenzoyl chloride (4659-45-4) + 2-(Benzyl-ethyl-amino)-1-(3-hydroxy-phenyl)-ethanone; hydrochloride (55845-90-4) → 3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate) (78426-04-7)

Guidance literature:

In trifluoroacetic acid; for 1.5h; Heating;

DOI:10.1002/jps.2600691219

Reference yield: 60.0%

3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate) (78426-04-7) → 3'-hydroxy-2-(ethylamino)acetophenone 3'-(2,6-dichlorobenzoate)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; Ambient temperature;

DOI:10.1002/jps.2600691219

Reference yield:

3'-hydroxy-2-(benzylethylamino)acetophenone 3'-(2,6-dichlorobenzoate) (78426-04-7) → etilefrine 3'-(2,6-dichlorobenzoate) hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / hydrogen, hydrochloric acid / 10percent palladium-on-carbon / methanol; H₂O / Ambient temperature

2: 1.) sodium borohydride, 2.) hydrochloric acid / 1.) methanol, 5 deg C, 2.) isopropanol, water

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1002/jps.2600691219

upstream raw materials:

2,6-Dichlorobenzoyl chloride

2-(Benzyl-ethyl-amino)-1-(3-hydroxy-phenyl)-ethanone; hydrochloride