(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Base Information

Chemical Name:(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine
CAS No.:600143-47-3
Molecular Formula:C₃₆H₅₇NOSi
Molecular Weight:547.94
Hs Code.:

Synonyms:(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Suppliers and Price of (3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

There total 7 articles about (3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: educt of 25

: 600143-41-7
(4R,6S,7R,10R)-7-tert-butyldimethylsilyloxy-6-methyl-octahydroquinolizidine-4-carbonitrile

: 600143-47-3
(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200300057

Reference yield:

: 600143-37-1
(3R,5R,8R,9RS)-5-(benzyloxypropyl)-8-tert-butyldimethylsilyloxy-3-phenyloxazolo[3,2-a]piperidine

: 600143-47-3
(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / diethyl ether; tetrahydrofuran / 48 h / 20 °C

2: 100 percent / H₂ / Pd(OH)2/C / ethanol / 96 h

3: 93 percent / potassium carbonate / acetonitrile / 12 h / Heating

4: thionyl chloride / CH₂Cl₂ / 1.5 h / Heating

5: 216 mg / LiHMDS / tetrahydrofuran / -78 °C

6: 93 percent / tetrahydrofuran / 20 °C

With thionyl chloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.200300057

Reference yield:

: 600143-38-2
[1R,3R,6R,1(1R)]-6-(3-benzyloxypropyl)-3-tert-butyldimethylsilyloxy-2-methyl-1-(1-phenyl-2-hydroxyethyl)piperidine

: 600143-47-3
(3R,4S,6R,10R)-3-tert-butyldimethylsilyloxy-6-decyl-4-methyloctahydroquinolizidine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / Pd(OH)2/C / ethanol / 96 h

2: 93 percent / potassium carbonate / acetonitrile / 12 h / Heating

3: thionyl chloride / CH₂Cl₂ / 1.5 h / Heating

4: 216 mg / LiHMDS / tetrahydrofuran / -78 °C

5: 93 percent / tetrahydrofuran / 20 °C

With thionyl chloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.200300057