S-1-methyl-2-oxo-2-phenylethyl thiobenzoate

Base Information

• Chemical Name: S-1-methyl-2-oxo-2-phenylethyl thiobenzoate
• CAS No.: 67902-75-4
• Molecular Formula: C₁₆H₁₄O₂S
• Molecular Weight: 270.352
• Mol file: 67902-75-4.mol

Synonyms:S-1-methyl-2-oxo-2-phenylethyl thiobenzoate

Chemical Property of S-1-methyl-2-oxo-2-phenylethyl thiobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of S-1-methyl-2-oxo-2-phenylethyl thiobenzoate

There total 5 articles about S-1-methyl-2-oxo-2-phenylethyl thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-mercapto-1-phenylpropan-1-one (13792-77-3,140237-90-7,140237-91-8) + benzoic acid (65-85-0,8013-63-6) → S-1-methyl-2-oxo-2-phenylethyl thiobenzoate (67902-75-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1039/c6ob02256a

Reference yield:

2-mercapto-1-phenylpropan-1-one (13792-77-3,140237-90-7,140237-91-8) + benzoyl chloride (98-88-4) → S-1-methyl-2-oxo-2-phenylethyl thiobenzoate (67902-75-4)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/ol0705200

Reference yield:

thiobenzoic acid (98-91-9) + 2-bromo-1-phenyl-1-propanone (2114-00-3) → S-1-methyl-2-oxo-2-phenylethyl thiobenzoate (67902-75-4)

Guidance literature:

With triethylamine; In diethyl ether;

DOI:10.1021/ja00485a030

upstream raw materials:

thiobenzoic acid

2-bromo-1-phenyl-1-propanone

2-mercapto-1-phenylpropan-1-one

benzoyl chloride

Downstream raw materials:

5-methyl-2,4-diphenylthiazole

benzyl benzothioate

thiobenzoic acid

Refernces

• 1、 Hatanaka, Toru,Yuki, Ryosuke,Saito, Ryota,Sasaki, Kaname. "α-Methylphenacyl thioesters as convenient thioacid precursors". supporting information. p. 10589 - 10592. Retrieved 2016/11/30.