2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

Base Information

Chemical Name:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester
CAS No.:1026563-85-8
Molecular Formula:C₂₄H₂₇ClN₂O₂S
Molecular Weight:443.01
Hs Code.:

Synonyms:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

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Chemical Property of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

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Technology Process of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

There total 10 articles about 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{Acetoxy-[2-butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-methyl}-4-thiophen-2-yl-butyric acid methyl ester

: 1026563-85-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 100 ℃; for 1h;
DOI:10.1021/jm00099a013

Reference yield:

: 20828-66-4
methyl 4-(thiophen-2-yl)butanoate

: 1026563-85-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

2: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

3: DBU / toluene / 1 h / 100 °C

With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In dichloromethane; toluene;
DOI:10.1021/jm00099a013

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 1026563-85-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

7: DBU / toluene / 1 h / 100 °C

With dmap; manganese(IV) oxide; sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00099a013