4-(2-Thienyl)butanoic acid methyl ester

Base Information

• Chemical Name: 4-(2-Thienyl)butanoic acid methyl ester
• CAS No.: 20828-66-4
• Molecular Formula: C9H12O2S
• Molecular Weight: 184.2554
• Hs Code.: 2934999090
• Mol file: 20828-66-4.mol

Synonyms:Methyl-4-(2-thienyl)butyrate;2-Thiophenebutanoic acid,methyl ester;4--buttersaeure-methylester;Methyl 4-(2-thienyl)butanoate;methyl 4-(thiophen-2-yl)butanoate;4-(2-Thienyl)butanoic acid methyl ester;4-thiophen-2-yl-butyric acid methyl ester;methyl 4-(thien-2-yl)butanoate;

Chemical Property of 4-(2-Thienyl)butanoic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.0121mmHg at 25°C
• Boiling Point: 260.6°Cat760mmHg
• Flash Point: 111.4°C
• PSA: 54.54000
• Density: 1.118g/cm³
• LogP: 2.24380

Purity/Quality:

99%min ^*data from raw suppliers

methyl4-(thiophen-2-yl)butanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Thienyl)butanoic acid methyl ester

There total 5 articles about 4-(2-Thienyl)butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 2-thiophenebutyric acid (4653-11-6) → methyl 4-(thiophen-2-yl)butanoate (20828-66-4)

Guidance literature:

With sulfuric acid; In methanol; for 8h; Reflux;

DOI:10.1002/chem.202003113

Reference yield: 95.0%

→ methyl 4-(thiophen-2-yl)butanoate (20828-66-4)

Guidance literature:

Reference yield:

2-thiophenebutyric acid (4653-11-6) → methyl 4-(thiophen-2-yl)butanoate (20828-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: 3 h / 20 °C

With thionyl chloride;

DOI:10.1016/j.bmcl.2005.04.064

upstream raw materials:

methanol

4-(thiophen-2-yl)butanoyl chloride

2-thiophenebutyric acid

4-oxo-4-thiophen-2-yl-butyric acid

Downstream raw materials:

4-(5-phenylthiophen-2-yl)butanoic acid

2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid methyl ester

2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-4-thiophen-2-yl-butyric acid

Refernces

• 1、 ?zen, Bilal,Fadaei Tirani, Farzaneh,Schenk, Kurt,Lin, Kun-Han,Scopelliti, Rosario,Corminboeuf, Clémence,Frauenrath, Holger. "Structure–Property Relationships in Bithiophenes with Hydrogen-Bonded Substituents". . p. 3348 - 3360. Retrieved 2021/02/01.
• 2、 Breen, C. J.,Devine, R.,Driver, R. B.,Findlay, J. B. C.,Kelada, M.,Kinsella, G. K.,Leonard, S.,Martin, D. S. D.,Stephens, J. C.,Walsh, J. M. D.. "Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase". . . Retrieved 2020/07/08.