4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

Base Information

Chemical Name:4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate
CAS No.:1227245-50-2
Molecular Formula:C₂₅H₂₅FN₄O₄
Molecular Weight:464.496
Hs Code.:

Synonyms:4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

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Chemical Property of 4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

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Technology Process of 4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

There total 6 articles about 4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206673-47-3
2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylamine

: 7693-46-1
4-Nitrophenyl chloroformate

: 1227245-50-2
4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1227245-50-2
4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 20 h / 160 °C / Autoclave

2: potassium carbonate; tetrabutylammomium bromide / palladium diacetate / water / 24 h / Inert atmosphere; Reflux

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 13 h / -2 - 20 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux

5: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 3 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; tetrabutylammomium bromide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dmap; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1206673-46-2
2-{2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethyl}isoindole-1,3-dione

: 1227245-50-2
4-nitrophenyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux

2: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 3 h / 0 - 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; dmap; In ethanol; dichloromethane;