(1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Base Information

• Chemical Name: (1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
• CAS No.: 365996-31-2
• Molecular Formula: C₁₉H₃₀N₄O₃S
• Molecular Weight: 394.538

Synonyms:(1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Chemical Property of (1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

There total 8 articles about (1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-trans-2-aminocyclohexanol (931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5) → (1S,2R)-N1-tert-Butoxycarbonyl-N2-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine (365996-31-2)

Guidance literature:

Multi-step reaction with 5 steps

1: CH₂Cl₂

2: 94 percent / pyridine

3: 47 percent / NaN₃ / dimethylformamide

4: H₂ / Pd/C

5: WSCI; HOBt / dimethylformamide

With pyridine; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.068

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (1S,2R)-N1-tert-Butoxycarbonyl-N2-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine (365996-31-2)

Guidance literature:

Multi-step reaction with 5 steps

1: CH₂Cl₂

2: 94 percent / pyridine

3: 47 percent / NaN₃ / dimethylformamide

4: H₂ / Pd/C

5: WSCI; HOBt / dimethylformamide

With pyridine; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.068

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → (1S,2R)-N1-tert-Butoxycarbonyl-N2-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine (365996-31-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 38 percent / 48 h / 160 °C

2: HCOONH₄ / Pd/C / methanol

3: CH₂Cl₂

4: 94 percent / pyridine

5: 47 percent / NaN₃ / dimethylformamide

6: H₂ / Pd/C

7: WSCI; HOBt / dimethylformamide

With pyridine; sodium azide; hydrogen; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.068

upstream raw materials:

tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

di-tert-butyl dicarbonate

(1S,2S)-trans-2-aminocyclohexanol

cyclohexane-1,2-epoxide

Downstream raw materials:

(+/-)-cis-N-[(5-Methyl-4,5,6,7-tetrahydrothiazolo-[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 365996-31-2 (1S,2R)-N₁-tert-Butoxycarbonyl-N₂-[(5-methyl-4,5, 6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send