(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate
CAS No.:149152-68-1
Molecular Formula:C₁₉H₂₆N₂O₆
Molecular Weight:378.425
Hs Code.:

Synonyms:(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Suppliers and Price of (2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 97%
1g
$ 302.50

Acrotein
(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 97%
0.5g
$ 201.66

Acrotein
(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 97%
5g
$ 907.50

ACHEMBLOCK
(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 95%
5G
$ 1075.00

ACHEMBLOCK
(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 95%
1G
$ 400.00

Total 3 raw suppliers

Chemical Property of (2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

95-3163%min ^*data from raw suppliers

(4S)-1-Boc-4-(Cbz-amino)-L-prolinemethylester 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

There total 7 articles about (2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 1217446-43-9
(2S,4S)-4-aminopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester hydrochloride

: 149152-68-1
(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield: 55.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 121148-01-4,1018667-18-9
(2S,4S)-4-amino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 149152-68-1
(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2008.11.010

Reference yield:

: 84520-68-3
N-tert-butoxycarbonyl-cis-4-azido-L-proline methyl ester

: 149152-68-1
(2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 4 h / 1551.4 Torr

2: aq. Na₂CO₃ / dioxane / 6 h / Ambient temperature

With hydrogen; sodium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1016/0040-4020(96)00924-6