(R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine

Base Information

• Chemical Name: (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine
• CAS No.: 261729-79-7
• Molecular Formula: C₁₇H₁₉NO₂S
• Molecular Weight: 301.409
• Mol file: 261729-79-7.mol

Synonyms:(R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine

Chemical Property of (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine

There total 1 articles about (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

potassium thiophenolate (3111-52-2) + [(2R)-2-(benzyloxycarbonylamino)propyl] 4-methylbenzenesulfonate (113707-74-7) → (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine (261729-79-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2.5h;

Reference yield: 99.0%

(R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine (261729-79-7) → (R)-1-methyl-2-phenylsylfanylethylamine (122673-69-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 17h; Heating;

Reference yield:

(R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine (261729-79-7) → N-(1-methyl-2-phenylsulfanyl)-N-[(S)-1-phenylethyl]formamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: 99 percent / 20 percent aq. KOH / ethanol / 17 h / Heating

2.1: Ti(Oiso-Pr)4 / 4 h / 80 °C

2.2: 70 percent / NaBH₄ / methanol / 2 h / 0 °C

3.1: 94 percent / Ac₂O / 2 h / 60 °C

4.1: 87 percent / NaIO₄ / H₂O; methanol / 17 h / 20 °C

5.1: trifluoroacetic acid / benzene / 2 h / 20 °C

5.2: BF₃*Et₂O / benzene / 2 h / 20 °C

With titanium(IV) isopropylate; potassium hydroxide; sodium periodate; acetic anhydride; trifluoroacetic acid; In methanol; ethanol; water; benzene; 1.1: Hydrolysis / 2.1: Condensation / 2.2: Reduction / 3.1: Formylation / 4.1: Oxidation / 5.1: Dehydration / 5.2: Cyclization;

upstream raw materials:

potassium thiophenolate

[(2R)-2-(benzyloxycarbonylamino)propyl] 4-methylbenzenesulfonate

Downstream raw materials:

(R)-1-methyl-2-phenylsylfanylethylamine

(R)-N-benzyl-1-methyl-2-phenylsulfanyl-ethylamine

N-benzyl-N-[(R)-1-methyl-2-phenylsulfanylethyl]formamide

N-[(R)-1-methyl-2-phenylsulfanylethyl]-N-[(R)-1-phenylethyl]formamide