Chemical Property of Stattic
Chemical Property:
- Vapor Pressure:3.04E-08mmHg at 25°C
- Melting Point:184℃
- Boiling Point:461.1°Cat760mmHg
- Flash Point:232.6°C
- PSA：88.34000
- Density:1.621g/cm3
- LogP:2.95680
- Storage Temp.:Store at +4°C
- Solubility.:DMSO: >20mg/mL
- XLogP3:0.7
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:210.99392881
- Heavy Atom Count:14
- Complexity:375
- Purity/Quality:
-
99%, *data from raw suppliers
Stattic *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi,Xn
- Statements:
20/21/22-36/37/38-22
- Safety Statements:
26-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
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Description
Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation.1 Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT3.2 Exhibits potent antitumor activity.3 Protects against angiotensin II-induced vascular dysfunction and hypertension.4?Stattic is an extremely useful tool to probe involvement of STAT3 in cellular signaling.
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Uses
Stattic is a Stat3 inhibitor which exhibited potent anti-tumor and induced chemo- and radio-sensitivity in nasopharyngeal carcinoma. Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5
