(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

Base Information

Chemical Name:(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide
CAS No.:1273329-14-8
Molecular Formula:C₂₃H₃₉NO₃
Molecular Weight:377.568
Hs Code.:

Synonyms:(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

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Technology Process of (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

There total 6 articles about (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 14565-47-0
N-succinimidyl laurate

: 1213638-14-2
(1R,3R)-3-amino-1-(4-methylphenyl)butane-1,4-diol

: 1273329-14-8
(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; chemoselective reaction;
DOI:10.1021/ol2001057

Reference yield: 81.0%

: 14565-47-0
N-succinimidyl laurate

: 1273329-04-6
(1R,3R)-3-amino-1-(4-methylphenyl)butane-1,4-diol acetate

: 1273329-14-8
(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; chemoselective reaction;
DOI:10.1021/ol2001057

Reference yield:

: 861896-82-4
(2R)-4-(methylphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}-butanoic acid

: 1273329-14-8
(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-(4-methylphenyl)prop-1-yl)dodecanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: hydrogenchloride / water / 4.25 h / 20 - 80 °C / Sonication

3: sodium tetrahydroborate / ethanol / 20 °C

4: 20 wt% Pd(OH)2/C; hydrogen / methanol / 40 °C

5: tetrahydrofuran / 20 °C

With hydrogenchloride; sodium tetrahydroborate; 20 wt% Pd(OH)2/C; hydrogen; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/ol2001057