3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

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Chemical Name:3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid
CAS No.:403857-10-3
Molecular Formula:C₃₅H₅₂N₂O₉S
Molecular Weight:676.872
Hs Code.:

Synonyms:3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

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Chemical Property of 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

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Technology Process of 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

There total 19 articles about 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 403857-09-0
4-[4-(4-{2-(butane-1-sulfonylamino)-2-[2-(2-carboxy-1,1-dimethyl-ethyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-butyl]-piperidine-1-carboxylic acid tert-butyl ester

: 403857-10-3
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol010282n

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 403857-10-3
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: 92 percent / 1N NaOH / dioxane

2.1: 95 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 °C

3.1: 40 percent / tetrahydrofuran

4.1: BH₃*THF

4.2: 90 percent / H₂O₂; NaOH

5.1: 80 percent / CBr₄; PPh₃ / CH₂Cl₂

6.1: 90 percent / NaH / dimethylformamide

7.1: 95 percent / H₂ / 10percent Pd/C / ethanol

8.1: 73 percent / DCC; DMAP / CH₂Cl₂ / 22 h / 0 - 20 °C

9.1: AcOH; H₂O / tetrahydrofuran / 20 h / 20 °C

10.1: PCC / CH₂Cl₂ / 4 h

11.1: KMnO₄ / acetone; H₂O / 24 h

12.1: 100 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With dmap; sodium hydroxide; potassium permanganate; borane-THF; oxalyl dichloride; carbon tetrabromide; water; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 2.1: Swern oxidation / 3.1: Wittig reaction;
DOI:10.1021/ol010282n

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 403857-10-3
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 14 steps

1.1: 90 percent / H₂; AcOH / 10percent Pd/C / 20 °C / 2585.81 Torr

2.1: 92 percent / 1N NaOH / dioxane

3.1: 95 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 °C

4.1: 40 percent / tetrahydrofuran

5.1: BH₃*THF

5.2: 90 percent / H₂O₂; NaOH

6.1: 80 percent / CBr₄; PPh₃ / CH₂Cl₂

7.1: 90 percent / NaH / dimethylformamide

8.1: 95 percent / H₂ / 10percent Pd/C / ethanol

9.1: 73 percent / DCC; DMAP / CH₂Cl₂ / 22 h / 0 - 20 °C

10.1: AcOH; H₂O / tetrahydrofuran / 20 h / 20 °C

11.1: PCC / CH₂Cl₂ / 4 h

12.1: KMnO₄ / acetone; H₂O / 24 h

13.1: 100 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With dmap; sodium hydroxide; potassium permanganate; borane-THF; oxalyl dichloride; carbon tetrabromide; water; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 3.1: Swern oxidation / 4.1: Wittig reaction;
DOI:10.1021/ol010282n