3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

Base Information

Chemical Name:3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide
CAS No.:1246865-45-1
Molecular Formula:C₂₃H₂₅N₅O₄
Molecular Weight:435.483
Hs Code.:

Synonyms:3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

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Chemical Property of 3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

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Technology Process of 3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

There total 7 articles about 3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-3-(prop-1-en-2-yl)-1H-indazole-6-carboxamide

: 1246865-45-1
3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; butan-1-ol; at 18 - 25 ℃; for 2.5h;

Reference yield:

: 170487-40-8
1H-indazole-6-carboxylic acid methyl ester

: 1246865-45-1
3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium phosphate / toluene / 0.17 h / 120 °C / Sealed tube

1.2: 2 h / 120 °C / Sealed tube

2.1: bromine / acetonitrile / 60 h / Inert atmosphere

3.1: sodium hydroxide; methanol / tetrahydrofuran / 0.25 h / 50 °C

4.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 50 °C

5.1: trisodium tris(3-sulfophenyl)phosphine; diisopropylamine; palladium diacetate / N,N-dimethyl-formamide / 1.5 h / 100 °C / Sealed tube

6.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone; butan-1-ol / 2.5 h / 18 - 25 °C

With 4-methyl-morpholine; methanol; potassium phosphate; copper(l) iodide; osmium(VIII) oxide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; trisodium tris(3-sulfophenyl)phosphine; bromine; palladium diacetate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 106-38-7
para-bromotoluene

: 1246865-45-1
3-(1,2-dihydroxypropan-2-yl)-N-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]-1-(4-methylphenyl)-1H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium phosphate / toluene / 0.17 h / 120 °C / Sealed tube

1.2: 2 h / 120 °C / Sealed tube

2.1: bromine / acetonitrile / 60 h / Inert atmosphere

3.1: sodium hydroxide; methanol / tetrahydrofuran / 0.25 h / 50 °C

4.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 50 °C

5.1: trisodium tris(3-sulfophenyl)phosphine; diisopropylamine; palladium diacetate / N,N-dimethyl-formamide / 1.5 h / 100 °C / Sealed tube

6.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone; butan-1-ol / 2.5 h / 18 - 25 °C

With 4-methyl-morpholine; methanol; potassium phosphate; copper(l) iodide; osmium(VIII) oxide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; trisodium tris(3-sulfophenyl)phosphine; bromine; palladium diacetate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; butan-1-ol;