6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER
• CAS No.: 170487-40-8
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 170487-40-8.mol

Synonyms:Indazole-6-carboxylicacid methyl ester;Methylindazole-6-carboxylate;NSC 144992;

Chemical Property of 6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 6.24E-05mmHg at 25°C
• Melting Point: 142-144℃
• Refractive Index: 1.648
• Boiling Point: 345.2 °C at 760 mmHg
• PKA: 12.43±0.40(Predicted)
• Flash Point: 162.6 °C
• PSA: 54.98000
• Density: 1.324 g/cm³
• LogP: 1.34950
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

Methyl1H-Indazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 1H-indazole-6-carboxylate?is used in organic synthesis.

Technology Process of 6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER

There total 18 articles about 6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-indazole-6-carboxylic acid (704-91-6) + methyl iodide (74-88-4) → 1H-indazole-6-carboxylic acid methyl ester (170487-40-8)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 83.0%

3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 1H-indazole-6-carboxylic acid methyl ester (170487-40-8)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 20 ℃; for 5h; Acidic aqueous solution;

Reference yield: 67.0%

ammonium tetrafluroborate (13826-83-0) + 3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 1H-indazole-6-carboxylic acid methyl ester (170487-40-8)

Guidance literature:

With hydrogenchloride; potassium acetate; sodium nitrite; In hexane; chloroform; water;

upstream raw materials:

3-amino-4-methyl benzoic acid methyl ester

ammonium tetrafluroborate

1H-indazole-6-carboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

1H-indazole-6-carboxylic acid

1-tert-butyl 6-methyl 1H-indazole-1,6-dicarboxylate

2-benzyl-1H-indazole-6-carboxylic acid methyl ester

1-methyl-1H-indazole-6-carboxylic acid methyl ester

Refernces

• 1、 -. "Compounds with higher PKG (protein kinase G) inhibitory activity and preparation method of compounds". Paragraph 0190; 0191; 0192; 0193; 0194; 0195. . Retrieved 2016/10/08.
• 2、 Kuntz, Kevin W.,Campbell, John E.,Keilhack, Heike,Pollock, Roy M.,Knutson, Sarah K.,Porter-Scott, Margaret,Richon, Victoria M.,Sneeringer, Chris J.,Wigle, Tim J.,Allain, Christina J.,Majer, Christina R.,Moyer, Mikel P.,Copeland, Robert A.,Chesworth, Richard. "The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat". supporting information. p. 1556 - 1564. Retrieved 2016/03/05.