4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

Base Information

Chemical Name:4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide
CAS No.:1372262-49-1
Molecular Formula:C₃₅H₅₀N₈O₅SSi
Molecular Weight:722.984
Hs Code.:

4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

Synonyms:4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

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Chemical Property of 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

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Technology Process of 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

There total 10 articles about 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-00-2
4-(3-Aminopropyl)morpholine

: 1372262-48-0
4-(4-(2(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoic acid

: 1372262-49-1
4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1372262-49-1
4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: ammonia; methanol / Ra-Ni / 4 h / 20 °C / 1551.49 Torr

3: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

4: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

5: hydrogenchloride; sodium hydroxide / water; methanol / 20 °C / pH 5

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4: Buchwald-Hartwig coupling;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372262-49-1
4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-(3-morpholinopropyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

4.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

5.1: hydrogenchloride; sodium hydroxide / water; methanol / 20 °C / pH 5

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4.1: Buchwald-Hartwig coupling;